1. Kobayashi S, Nakano K, Watanabe E, Ishigaki T, Ohno N, Yuji K, Oyaizu N, Asanuma S, Yamagishi M, Yamochi T, Watanabe N, Tojo A, Watanabe T, Uchimaru K. CADM1 expression and stepwise downregulation of CD7 are closely associated with clonal expansion of HTLV-1-infected cells in adult T-cell leukemia/lymphoma. Clin Cancer Res 2014, in press (DOI: 10.1158/1078-0432.CCR-13-3169)
  2. Tsukasaki K, Imaizumi Y, Tokura Y, Ohshima K, Kawai K, Utsunomiya A, Amano M, Watanabe T, Nakamura S, Iwatsuki K, Kamihira S, Yamaguchi K, Shimoyama M. Meeting report on the possible proposal of an extra-nodal primary cutaneous variant in the lymphoma type of adult T-cell leukemia-lymphoma. J Dermatol 41(1):26-28. Jan. 2014 (doi: 10.1111/1346-8138.12374)
  3. Togano T, Nakashima M, Watanabe M, Umezawa K, Watanabe T, Higashihara M, Horie R. Synergistic Effect of 5-Azacytidine and NF-κB Inhibitor DHMEQ on Apoptosis Induction in Myeloid Leukemia Cells. Oncol Res 20(12):571-577, 2013 (doi: 10.3727/096504013X13775486749371)
  4. Asanuma S, Yamagishi M, Kawanami K, Nakano K, Sato-Otsubo A, Muto S, Sanada M, Yamochi T, Kobayashi S, Utsunomiya A, Iwanaga M, Yamaguchi K, Uchimaru K, Ogawa S, Watanabe T. Adult T-cell leukemia cells are characterized by abnormalities of Helios expression that promotes T-cell growth. Cancer Sci 104(8):1097-1106, Aug. 2013 (doi: 10.1111/cas.12181)
  5. Mahieux R, Watanabe T. Forefront studies on HTLV-1 oncogenesis. Front Microbiol 4:156, Jun. 2013 (doi: 10.3389/fmicb.2013.00156)
  6. Ly BT, Chi HT, Yamagishi M ,Kano Y, Hara Y, Nakano K, Sato Y, Watanabe T. Inhibition of FLT3 expression by green tea catechins in FLT3 mutated-AML cells. PLoS One 8(6):e66378, Jun. 2013 (doi: 10.1371/journal.pone.0066378)
  7. Nakano K, Ando T, Yamagishi M, Yokoyama K, Ishida T, Ohsugi T, Tanaka Y, Brighty D-W, Watanabe T. Viral interference with host mRNA surveillance, the nonsense-mediated mRNA decay (NMD) pathway, through a new function of HTLV-1 Rex: implications for retroviral replication. Microbes Infect 15(6-7):491-505, Jun. 2013 (doi: 10.1016/j.micinf.2013.03.006)
  8. Yuki H, Ueno S, Tatetsu H, Niiro H, Iino T, Endo S, Kawano Y, Komohara Y, Takeya M, Hata H, Okada S, Watanabe T, Akashi K, Mitsuya H, Okuno Y. PU.1 is a potent tumor suppressor in classical Hodgkin lymphoma cells. Blood 121(6):962-970, Feb. 2013 (doi: 10.1182/blood-2012-05-431429)


  1. Yamagishi M, Watanabe T.
    Molecular Hallmarks of Adult T Cell Leukemia (Review Article).
    Front. Microbiol. 3:334. Sep. 2012(doi: 10.3389/fmicb.2012.00334) Epub
  2. Iwanaga M, Watanabe T, Yamaguchi K.
    Adult T-cell leukemia: a review of epidemiological evidence.
    Front. Microbiol (Review) 2012;3:322. doi: 10.3389/fmicb.2012.00322.
  3. Nakano K, Watanabe T.
    HTLV-1 Rex: the courier of viral messages, making use of the host vehicle,
    Front. Microbiol (Review) 2012;3:330. doi: 10.3389/fmicb.2012.00330.
  4. Kobayashi-Ishihara M, Yamagishi M, Hara T, Matsuda Y, Takahashi R, Miyake A, Nakano K, Yamochi T, Ishida T, Watanabe T.
    HIV-1-encoded antisense RNA suppresses viral replication for a prolonged period.
    Retrovirology, 9:38, 17pp. Aug. 2012(doi:10.1186/1742-4690-9-38) Epub
  5. Ando T, Imamura H, Suzuki R, Hideki Aizaki H, Watanabe T, Wakita T, Suzuki T. Visualization and Measurement of ATP Levels in Living Cells Replicating Hepatitis C Virus Genome RNA.
    PLoS Pathogens, 2012;8(3):e1002561
  6. Watanabe M, Itoh K, Togano T, Kadin M-E., Watanabe T, Higashihara M, Horie R. Ets-1 Activates Overexpression of JunB and CD30 in Hodgkin Lymphoma and Anaplastic Large- Cell Lymphoma.
    Am J Pathol, 180(2):831-838, Feb. 2012
  7. Yamagishi M, Nakano K, Miyake A, Yamochi T, Kagami Y, Tsutsumi A, Matsuda Y, Sato-Otsubo A, Muto S, Utsunomiya A, Yamaguchi K, Uchimaru K, Ogawa S, Watanabe T. Polycomb-mediated loss of miR-31 activates NIK-dependent NF-kB pathway in adult T-cell leukemia and other cancers.
    Cancer Cell, 21(1):121-135, Jan. 2012
  8. Uota S, Dewan MZ, Saitoh Y, Muto S, Itai A, Utsunomiya A, Watanabe T, Yamamoto N, Yamaoka S. An IκB kinase 2 inhibitor IMD-0354 suppresses the survival of adult T-cell leukemia cells.
    Cancer Sci, 103(1):100-106, Jan. 2012


  1. Watanabe M, Nakano K, Togano T, Nakashima M, Higashihara M, Kadin M-E, Watanabe T, Horie R.
    Targeted repression of overexpressed CD30 downregulates NF-κB and ERK1/2 pathway in Hodgkin lymphoma cell lines.
    Oncol Res, 2011;19(10-11):463-469
  2. Takamori A, Hasegawa A, Utsunomiya A, Maeda Y, Yamano Y, Masuda M, Shimizu Y, Tamai Y, Sasada A, Zeng N, Choi I, Uike N, Okamura J, Watanabe T, Masuda T, Kannagi M.
    Functional impairment of Tax-specific but not cytomegalovirus-specific CD8+ cytotoxic T lymphocytes in a minor population of asymptomatic human T-cell leukemia virus type 1-carriers.
    Retrovirology, 8:100, 15pp, Dec. 2011(doi:10.1186/1742-4690-8-100) Epub
  3. Suzuki K, Ishida T, Yamagishi M, Ahlenstiel C, Swaminathan S, Marks K, Murray D, McCartney EM, Beard MR, Alexander M, Purcell DF, Cooper DA, Watanabe T, Kelleher AD.
    Transcriptional gene silencing of HIV-1 through promoter targeted RNA is highly specific.
    RNA Biol. 8(6):1035-1046, Nov. 2011
  4. Vu HA, Beppu Y, Chi HT, Sasaki K, Yamamoto H, Xinh PT, Tanii T, Hara Y, Watanabe T, Sato Y, Ohdomari I .
    Green Tea Epigallocatechin Gallate Exhibits Anticancer Effect in Human Pancreatic Carcinoma Cells via the Inhibition of Both Focal Adhesion Kinase and Insulin-Like Growth Factor-I Receptor.
    J Biomed Biotechnol 290516(8pp), Jan. 2011 (Epub)
  5. Yamamoto K, Ishida T, Nakano K, Yamagishi M, Yamochi T, Tanaka Y, Furukawa Y, Nakamura Y, Watanabe T.
    SMYD3 interacts with HTLV-1 Tax and regulates sub-cellular localization of Tax.
    Cancer Sci, 102(1): 260-266, Jan. 2011


  1. Chi HT, Ly BTK, Taguchi T, Watanabe T, Sato Y.
    All-trans retinoic acid inhibits KIT activity and induces apoptosis in gastrointestinal stromal tumor GIST-T1 cell line by affecting on the expression of survivin and Bax protein.
    J Exp Clin Cancer Res 16;29(1):165, Dec. 2010 (epub)
  2. Nakashima M, Ishii Y, Watanabe M, Togano T, Umezawa K, Higashihara M, Watanabe T, Horie R.
    The side population, a precursor of Hodgkin and Reed-Sternberg cells, as a target for NF-κB inhibitors in Hodgkin lymphoma.
    Cancer Sci 101(11):2490-2946, Nov. 2010
  3. Misawa A, Katayama R, Koike S, Tomida A, Watanabe T, Fujita N.
    AP-1-dependent miR-21 Expression Contributes to Chemoresistance in Cancer Stem Cell-Like SP Cells.
    Oncol Res 19(1), 23-33, 2010
  4. Kamihira S, Iwanaga M, Sasaki D, Yamano Y, Okayama A, Umeki K, Kubota R, Izumo S, Yamaguchi K, Watanabe T, Satake M.
    Intra-and inter-laboratory Variability in HTLV-1 Proviral Load Quantification Using Real-Time Polymerase Chain Reaction Assays: A Multi-Center Study.
    Cancer Sci 101(11):2361-2367, Nov. 2010
  5. Masuda M, Ohta T, Maruyama T, Ito A, Hayashi T, Tsukasaki K, Kamihira S, Yamaoka S, Hoshino H, Yoshida T, Watanabe T, StanbridgeE-J, Murakam Y.
    CADM1 interacts with Tiam1 and promotes invasive phenotype of human T-cell leukemia virus type I-transformed cells and adult T-cell leukemia cells.
    J Biol Chem 285(20): 15511-15522, May 2010
  6. Iwanaga M, Watanabe T, Utsunomiya A, Okayama A, Uchimaru K, Koh K-R, Ogata M, Kikuchi H, Sagara Y, Uozumi K, Mochizuki M, Tsukasaki K, Saburi Y, Yamamura M, Tanaka J, Moriuchi Y, Hino S, Kamihira S, Yamaguchi K, for the Joint Study on Predisposing Factors of ATL Development (JSPFAD) investigators.
    Human T-cell leukemia virus type I (HTLV-1) proviral load and disease progression in asymptomatic HTLV-1 carriers: a nationwide prospective study in Japan.
    Blood 116(8):1211-1219,
    Aug. 2010
  7. Sasaki D, Doi Y, Hasegawa H, Yanagihara K, Tsukasaki K, Iwanaga M, Yamada Y, Watanabe T, Kamihira S.
    High Human T Cell Leukemia Virus Type-1(HTLV-1) Provirus Load in Patients with HTLV-1 Carriers Complicated with HTLV-1-unrelated disorders.
    Virol J 7:81, 7pp. Apr. 2010
  8. Hagiwara K, Kondoh Y, Ueda A, Yamada K, Goto H, Watanabe T, Nakata T, Osada H, Aida Y .
    Discovery of novel antiviral agents directed against the influenza A virus nucleoprotein using photo-cross-linked chemical arrays.
    Biochem Biophys Res Commun 394(3): 721-727, Apr. 2010
  9. Iejima D, Minegishi Y, Takenaka K, Siswanto A, Watanabe M, Huang L, Watanabe T, Tanaka F, Kuroda M, Gotoh N.
    FRS2β, a potential prognostic gene for non-small cell lung cancer, encodes a feedback inhibitor of EGF receptor family members via ERK binding.
    Oncogene 29, 3087–3099, 15 Mar. 2010
  10. Miyake A, Ishida T, Yamagishi M, Hara T, Umezawa K, Watanabe T, Horie R.
    Inhibition of active HIV-1 replication by NF-kB inhibitor DHMEQ.
    Microbes Infect 12 400-408, 19 Feb. 2010
  11. Chi HT, Vu HA, Iwasaki R, Nagamura F, Tojo A, Watanabe T, Sato Y.
    Detection of exon 12 type A mutation of NPM1 gene in IMS-M2 cell line.
    Leuk Res 34(2):261-262, Feb. 2010


  1. Togano T, Sasaki M, Watanabe M, Nakashima M, Tsuruo T, Umezawa K, Higashihara M, Watanabe T, Horie R.
    Induction of oncogene addiction shift to NF-κB by camptothecin in solid tumor cells.
    Biochem Biophys Res Commun 390(1):60-64, Dec. 2009
  2. Chi HT, Vu HA, Iwasaki R, Thao LB, Hara Y, Taguchi T, Watanabe T, Sato Y.
    Green tea (-)-epigalocatechin-3-gallate inhibits KIT activity and causes caspase-dependent cell death in gastrointestinal stromal tumor including imatinib-resistant cells.
    Cancer Biol Ther 8(20):1-6, Oct. 2009
  3. Yamagishi M, Ishida T, Miyake A, Cooper DA, Kelleher AD, Suzuki K, Watanabe T.
    Retroviral delivery of Promoter-targeted shRNA induces long-term silencing of HIV-1 transcription.
    Microbes Infect 11:500-508, Apr. 2009
  4. Thao LB, Vu HA, Yasuda K, Taniguchi S, Yagasaki F, Taguchi T, Watanabe T, Sato Y.
    Cas-L was overexpressed in imatinib-resistant gastrointestinal stromal tumor cells.
    Cancer Biol Ther 8(8):683-688, Apr. 2009
  5. Dabaghmanesh N, Matsubara A, Miyake A, Nakano K, Ishida T, Katano H, Horie R, Umezawa K, Watanabe T.
    Transient inhibition of NF-kB by DHMEQ induces cell death of primary effusion lymphoma without HHV-8 reactivation.
    Cancer Sci 100:737–746, Apr. 2009
  6. Miyazaki K, Inoue S, Yamada K, Watanabe M, Liu Q, Watanabe T, Tamamori Adachi M, Tanaka Y, Kitajima S.
    Differential usage of alternate promoters of thehuman stress response gene ATF3 in stress response and cancer cells.
    Nucleic Acids Res 37:1438–1451, Apr. 2009
  7. Shimizu Y, Takamori A, Utsunomiya A, Kurimura M, Yamano Y, Hishizawa M, Hasegawa A, Kondo F, Kurihara K, Harashima N, Watanabe T, Okamura J, Masuda T, Kannagi M.
    Impaired Tax-specific T-cell responses with insufficient control of HTLV-1 in a subgroup of individuals at asymptomatic and smoldering stages.
    Cancer Sci 100:481-489, Mar. 2009
  8. Iwasaki R, Ito K, Ishida T, Hamanoue M, Adachi S, Watanabe T, Sato Y.
    Catechin, green tea component, causes caspase-independent necrosis-like cell death in chronic myelogenous leukemia.
    Cancer Sci 100:349-356, Feb. 2009
  9. Matsuo J, Tsukumo Y, Sakurai J, Tsukahara S, Hae-Ryong P, Shin-ya K, Watanabe T, Tsuruo T, Tomida A.
    Preventing the unfolded protein response via aberrant activation of 4E-BP1 by versipelostatin.
    Cancer Sci 100:327-333, Feb. 2009
  10. Tsukasaki K, Hermine O, Bazarbachi A, Ratner L, Ramos JC, Harrington W, O’Mahony D, Janik JE, Bittencourt AL, Taylor GP, Yamaguchi K, Utsunomiya A, Tobinai K, Watanabe T.
    Definition, Prognostic Factors, Treatment and Response Criteria of Adult T-cell Leukemia-Lymphoma: A Proposal from an International Consensus Meeting.
    J Clin Oncol 27:453-459, Jan. 2009


  1. Uchimaru K, Nakamura Y, Tojo A, Watanabe T, Yamaguchi K.
    Factors predisposing to HTLV-1 infection in residents of the greater Tokyo area.
    Int J Hematol 88:565-570, Dec. 2008
  2. Watanabe M, Nakashima M, Togano T, Higashihara M, Watanabe T.
    Identification of the Rela domain responsible for action of a new NFkappaB inhibitor DHMEQ.
    Biochem Biophys Res Commun 376:310-314, Nov. 2008
  3. Kurata A, Katayama R, Watanabe T, Tsuruo T, Fujita N.
    TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling.
    Cancer Sci 99:1827-1834, Sep. 2008
  4. Suzuki K, Juelich T, Lim H, Ishida T, Watanabe T, Cooper DA, Rao S, Kelleher AD.
    Closed chromatin architecture is induced by an RNA duplex targeting the HIV-1 promoter region.
    J Biol Chem 283:23353-23363, 2008
  5. Makishi S, Okudaira T, Ishikawa C, Sawada S, Watanabe T, Hirashima M, Sunakawa H, Mori N.
    A modified version of galectin-9 induces cell cycle arrest and apoptosis of Burkitt and Hodgkin lymphoma cells.
    Br J Haematol 142:583-594, Aug. 2008
  6. Miyake A, Dewan MZ, Ishida T, Watanabe M, Honda M, Sata T, Yamamoto N, Umezawa K, Watanabe T, Horie R.
    Induction of apoptosis in Epstein-Barr virus-infected B-lymphocytes by the NF-κB inhibitor DHMEQ.
    Microbes Infect 10:748-756, Jun. 2008
  7. Saitoh Y, Yamamoto N, Dewan MDZ, Sugimoto H, Martinez VJ, Iwasaki Y, Matsu-bara K, Qi X, Saitoh T, Imoto I, Inazawa J, Utsunomiya A, Watanabe T, MasudaT, Yamamoto N, Yamaoka S.
    Overexpressed NF-κB-inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells.
    Blood 111:5118-5129, May 2008
  8. Franchina M, Woo AJ, Dods J, Karimi M, Ho D, Watanabe T, Spagnolo DV, Abraham LJ.
    The CD30 gene promoter microsatellite binds transcription factor Yin Yang 1 (YY1) and shows genetic instability in anaplastic large cell lymphoma.
    J Pathol 214: 65-74, 2008
  9. Watanabe M, Ogawa Y, Itoh K, Koiwa T, Kadin ME, Watanabe T, Okayasu I, Higashihara M, Horie R.
    Hypomethylation of CD30 CpG islands with aberrant JunB expression drives CD30 induction in Hodgkin lymphoma and anaplastic large cell lymphoma.
    Lab Invest 88: 48-57, Jan. 2008


  1. Han M-Y, Kosako H, Watanabe T, Hattori S.
    ERK MAP Kinase Regulates Actin Organization 1 and Cell Motility 2 by Phosphorylating the Actin Cross-Linking Protein EPLIN.
    Mol Cell Biol 27:8190–8204, Dec. 2007
  2. Katano H, Sato Y, Hoshino S, Tachikawa N, Oka S, Morishita Y, Ishida T, Watanabe T, Rom WN, Mori S, Sata T, Weiden MD, Hoshino Y.
    Integration of HIV-1 caused STAT3-associated B cell lymphoma in an AIDS patient.
    Microbes Infec 9:1581-1589, Nov. –Dec. 2007
  3. Matsuoka M, Watanabe T, Kannagi M, Bangham C, Grassmann R, Marriott SJ, Green P, Jeang K-T.
    Meeting Report on the 13th International Conference on Human Retrovirology: Human T-Cell Leukemia Virus Research-30Years after Adult T-Cell Leukemia.
    Cancer Res 67:10638-10641, Nov. 2007
  4. Ohsugi T, Kumasaka T, Okada S, Ishida T, Yamaguchi K, Horie R, Watanabe T, Umezawa K.
    Dehydroxymethylepoxyquinomicin (DHMEQ) therapy reduces tumor formation in mice inoculated with Tax-deficient adult T-cell leukemia–derived cell lines.
    Cancer Lett 257:206–215, Nov. 2007
  5. Horie R, Ishida T, Maruyama-Nagai M, Ito K, Watanabe M, Yoneyama A, Higashihara M, Kimura S, Watanabe T.
    TRAF activation of C/EBPb (NF-IL6) via p38 MAPK induces HIV-1 gene expression in monocytes/macrophages.
    Microbes Infect 9:721-728, May 2007
  6. Watanabe M, Dewan Md. Z, Taira M, Shoda M, Honda M, Sata T, Higashihara M, Kadin ME, Watanabe T, Yamamoto N, Umezawa K, Horie R.
    IkBa independent induction of NF-kB and its inhibition by DHMEQ in Hodgkin-Reed-Sternberg cells.
    Lab Invest 87:372–382, Apr. 2007


  1. Ishida T, Hamano A, Koiwa T, Watanabe T.
    5' long terminal repeat (LTR)-selective methylation of latently infected HIV-1 provirus that is demethylated by reactivation signals.
    Retrovirology 3:69 (e-pub), Oct. 2006
  2. Sugita S, Takase H, Yoshida T, Sugamoto Y, Watanabe T, Mochizuki M.
    Intraocular soluble IL-2 receptor alpha in a patient with adult T-cell Leukemia within traocular invasion.
    Br J Ophthalmol 90(9):1204-1206, 2006
  3. Horie R, Watanabe T, Umezawa K.
    Blocking NF-kappaB as a potential strategy to treat adult T-cell leukemia/lymphoma.
    Drug News Perspect 19(4):201-209, May 2006
  4. Miyake A, Ibuki K, Enose Y, Suzuki H, Horiuchi R, Motohara M, Saito N, Nakanose T, Honda M, Watanabe T, Miura T, Hayami M.
    Rapid dissemination of a psthogenic siman/human immunodeficiency virus to systemic organs and active replication in lymphoid tissues following intrarectal infection.
    J Gen Virol 87(Pt 5):1311-1320, May 2006
  5. Horie R, Watanabe M, Okamura T, Taira M, Higashihara M, Watanabe T, Umezawa K.
    DHMEQ, a new NF-kB inhibitor induces apoptosis of chronic lymphocytic leukemia cells and enhances effect of fludarabine.
    Leukemia 20, 800-806, May 2006
  6. Uchihara JN, Matsuda T, Okudaira T, Ishikawa C, Masuda M, Horie R, Watanabe T, Ohta T, Takasu N, Mori N.
    Transactivation of the ICAM-1 gene by CD30 in Hodgkin's Lymphoma.
    Int J Cancer 118:1098-107, Mar. 2006
  7. Kamoi K, Yamamoto K, Misawa A, Miyake A, Ishida T, Tanaka Y, Mochizuki M, Watanabe T.
    SUV39H1 interacts with HTLV-1 Tax and abrogates Tax transactivation of HTLV-1 LTR.
    Retrovirology 3,5, Jan. 2006 (epub)
  8. Ohsugi T, Kumasaka T, Ishida A, Ishida T, Horie R, Watanabe T, Umezawa K, Yamaguchi K .
    In vitro and in vivo antitumor activity of the NF-kB inhibitor DHMEQ in the human T-cell leukemia virus type 1-transformed cell line, HUT-102.
    Leuk Res 30:90-97, Jan. 2006
  9. Nishioka C, Takemoto S, Kataoka S, Yamanaka S, Moriki T, Shoda M, Watanabe T, Taguchi H.
    Serum level of soluble CD30 correlates with the aggressiveness of adult T-cell leukemia/lymphoma.
    Cancer Sci 96(11):810-815. Nov. 2005
  10. Watanabe M, Ohsugi T, Shoda M, Ishida T, Aizawa S, Maruyama-Nagai M, Utsunomiya A, Koga S, Yamada Y, Kamihira S, Okayama A, Kikuchi H, Uozumi K, Yamaguchi K, Higashihara M, Umezawa K, Watanabe T, Horie R.
    Dual targeting of transformed and untransformed HTLV-1-infected T-cells by DHMEQ, a potent and selective inhibitor of NF-kB, as a strategy for chemoprevention and therapy of adult T cell leukemia.
    Blood 106: 2462 - 2471, Oct. 2005
  11. Watanabe M, Sasaki M, Itoh K, Higashihara M, Umezawa K, Kadin ME, Abraham LJ, Watanabe T, Horie R.
    JunB induced by constitutive CD30-ERK1/2 MAPK signaling activates the CD30 promoter in anaplastic large cell lymphoma and Reed-Sternberg cells of Hodgkin lymphoma.
    Cancer Res 65:7628-7634, Sep. 2005
  12. Dewan Md.Z, Watanabe M, Ahmed S, Terashima K, Horiuchi S, Sata T, Honda M, Ito M, Watanabe T, Horie R, Yamamoto N.
    Hodgkin's Lymphoma Cells Are Efficiently Engrafted and Expressed Tumor Marker CD30 with Constitutive NF-kB Activity in Unconditioned NOD-SCID/gcnull (NOG) Mice.
    Cancer Sci 96:466-473, Aug. 2005
  13. Ohsugi T, Horie R, Kumasaka T, Ishida A, Ishida T, Yamaguchi K, Watanabe T, Umezawa K, Urano T .
    In vivo Antitumor Activity of the NF-κB Inhibitor Dehydroxymethylepoxyquinomicin in a Mouse Model of Adult T-cell Leukemia.
    Carcinogenesis 26:1382-1388, Aug. 2005
  14. Nonaka M, Horie R, Itoh K, Watanabe T, Yamamoto N, Yamaoka S.
    Aberrant NF-κB2/p52 expression in Hodgkin/Reed-Sternberg cells and CD30-transformed rat fibroblasts.
    Oncogene 24:3976-3986, Jun. 2005
  15. Higuchi M, Matsuda T, Mori N, Yamada Y, Horie R, Watanabe T, Takahashi M, Oie M, Fujii M.
    Elevated expression of CD30 in adult T-cell leukemia cell lines:possible role in constitutive NF-kB activation.
    Retrovirology 2, 29, May 2005 (epub)
  16. Tanaka G, Okayama A, Watanabe T, Aizawa S, Stuver S, Mueller N, Hsieh C-C, Tsubouchi H.
    The clonal expansion of HTLV-1 infected cells: A comparison between seroconverters and long-term carriers.
    J Inf Dis 191:1140-1147, 2005
  17. Watanabe M, Dewan Z, Okamura T, Sasaki M, Itoh K, Higashihara M, Mizoguchi H, Honda M, Sata T, Watanabe T, Yamamoto N, Umezawa K, Horie R.
    A novel NF-kB inhibitor DHMEQ selectively targets constitutive NF-kB activity and induces apoptosis of multiple myeloma cells in vitro and in vivo.
    Int J Cancer 114:32-38, Mar. 2005
  18. Iwata S, Souta-Kuribara A, Sasaki T, Kobayashi H, Yamakawa A, Hosono O, Kawasaki H, Tanaka H, Dang NH, Watanabe T, Arima N, Yamaoka S, Morimoto C.
    HTLV-I Tax induces and associates with Crk-associated substrate lymphocyte type (Cas-L).
    Oncogene 24:1262-1271, Feb. 2005
  19. Dewan MZ, Watanabe M, Terashima K, Aoki M, Sata T, Honda M, Ito M, Yamaoka S, Watanabe T, Horie R, Yamamoto N.
    Prompt tumor formation and maintenance of constitutive NF-kappaB activity of multiple myeloma cells in NOD/SCID/gammacnull mice.
    Cancer Sci 95:564-568, Jul. 2004
  20. Horie R, Watanabe M, Ishida T, Koiwa T, Aizawa S, Itoh K, Higashihara M, Kadin ME, Watanabe T.
    The NPM-ALK oncoprotein abrogates CD30 signaling and constitutive NF-kB activation in anaplastic large cell lymphoma.
    Cancer Cell 5, 353-364, Apr. 2004
  21. Ohsugi T, Yamaguchi K, Kumasaka T, Ishida T, Horie R, Watanabe T, Sakio N, Fujimoto T, Sakamoto N, Urano T.
    Rapid tumor death dodel for evaluation of new therapeutic agents for adult T-cell leukemia.
    Lab Invest 84:263-266, Feb. 2004
  22. Habelhah H, Takahashi S, Cho SG, Kadoya T, Watanabe T, Ronai Z.
    Ubiquitination-dependent translocation of TRAF2 to the insoluble cellular fraction is required for its activation of JNK but not of p38 or NF-kB.
    EMBO J 23:322-332, Jan. 2004
  23. Horie R, Watanabe T.
    The biological basis of Hodgkin's lymphoma.
    Drug News Perspect 16(10):649-656. Dec. 2003
  24. Watanabe M, Ogawa Y, Ito K, Higashihara M, Kadin ME, Abraham LJ, Watanabe T, Horie R.
    AP-1 mediated relief of repressive activity of the CD30 promoter microsatellite in Hodgkin and Reed-Sternberg cells.
    Am J Pathol 163:633-641, Aug. 2003
  25. Tanaka J, Ishida T, Choi B.-I, Watanabe T, Yasuda J, Iwakura, Y.
    Latent HIV-1 reactivation in transgenic mice requires cell cycle-dependent demethylation of CREB/ATF sites in the LTR.
    AIDS 17:167-175, Jan. 2003
  26. Horie R, Higashihara M, Watanabe T.
    Hodgkin's lymphoma and CD30 signal transduction.
    Int J Hematol 77(1):37-47, Jan. 2003
  27. Koiwa T, Hamano-Usami A, Ishida T, Okayama A, Yamaguchi K, Kamihira S, Watanabe T.
    5'-LTR-selective CpG methylation of latent HTLV-1 provirus in vitro and in vivo.
    J Virol 76:9389-9397, Sep. 2002
  28. Yamaguchi K, Watanabe T.
    Human T lymphotropic virus type-I and adult T-cell leukemia in Japan.
    Int J Hematol 76 Suppl 2:240-245, Aug. 2002
  29. Horie R, Watanabe T, Ito K, Morisita Y, Watanabe M, Ishida T, Higashihara M, Kadin M, Watanabe T.
    Cytoplasmic aggregation of TRAF2 and TRAF5 proteins in the Hodgkin-Reed-Sternberg cells.
    Am J Pathol 160:1647-1654, May 2002
  30. Horie R, Watanabe T, Morishita Y, Ito K, Ishida T, Kanegae Y, Saito I, Higashihara M, Mori S, Kadin ME, Watanabe T.
    Ligand-independent signaling by overexpressed CD30 drives NF-kB activation in Hodgkin-Reed Sternberg cells.
    Oncogene 21:2493-2503, Apr. 2002
  31. Satoh M, Toma H, Sugahara K, Etoh K, Shiroma Y, Kiyuna S, Takara M, Matsuoka M, Yamaguchi K, Nakada K, Fujita K, Kojima S, Hori E, Kamihira S, Sato Y, Tanaka Y, Watanabe T.
    Involvement of IL-2/IL-2R system activation by parasite antigen in polyclonal expansion of CD4+25+ HTLV-1-infected T-cells in human carriers of both HTLV-1 and S. stercoralis. Oncogene 21:2466-2475, Apr. 2002
  32. Sakurada S, Katano H, Sata T, Ohkuni H, Watanabe T, Mori S.
    Effective human herpesvirus 8 infection of human umbilical vein endothelial cells by cell-mediated transmission.
    J Virol 75:7717-7722, Aug. 2001
  33. Koike R, Iizuka T, Watanabe T , Miyasaka N.
    GOR gene product can not cross-react to hepatitis C virus in human beings.
    Clin. Exp. Immunol 124:429-434, Jan. 2001
  34. Sugita S, Taguchi C, Takase H, Sagawa K, Sueda J, Fukushi K, Hikita N, Watanabe T, Itoh K, Mochizuki M.
    Soluble fas ligand and soluble fas in ocular fluid of patients with uveitis.
    Br J Ophthalmol. 84:1130-4, Oct. 2000
  35. Mochizuki M, Sugita S, Ishikawa N, Watanabe T. Immunoregulation by aqueous humor.
    Cornea 19(3 Suppl):S24-S25, 2000
  36. Trovato R, Cereseto A, Takemoto S Gessain A, Watanabe T, Waldmann T, Franchini G.
    Deletion of the p16ink4a gene in ex vivo acute atll cells and methylation of p16ink4a promoter in HTLV-I-infected T-cell lines.
    AIDS Res Hum Retrovirus 16: 709-713, May 2000
  37. Tanaka R, Satoh H, Moriyama M, Satoh K, Morishita Y, Watanabe T, Nakamura Y, Mori S.
    Intronic U50 samll nucleolar RNA (snoRNA) host gene of no protein-coding potential is mapped at the chromosome break poit t(3;6)(q27;q15) of human B-cell lymphoma.
    Genes to Cells 5: 277-287, Apr. 2000
  38. Iizuka T, Tanaka T, Suematsu M, Miura S, Watanabe T, Koike R, Ishimura Y, Ishii H, Miyasaka N, Miyasaka M.
    Stage-specific expression of mucosal addressin cell adhesion molecule-1 during embryogenesis in rats.
    J Immunol 164:2463-2471, Mar. 2000

Reviews and Textbook

  1. Yoshida M, Seiki M, Hattori S, Watanabe T.
    Genome structure of human T-cell leukemia virus and its involvement in the development of adult T-cell leukemia/lymphoma.
    In "Human T-cell Leukemia/Lymphoma Viruses", eds. Gallo RC, Essex ME and Gross L. Cold Spring Harbor Laboratory, N. Y., pp 141-148, 1984
  2. Yoshida M, Hattori S, Kiyokawa T, Watanabe T, Seiki M.
    The molecular biology of human T-cell leukemia virus.
    In "Symposium of the Society for General Microbiology. Viruses and Cancer", eds. Rigby PWJ and Wilkie NM, Cambridge University Press, 1984
  3. Yoshida M, Kiyokawa T, Watanabe T, Hattori S, Fujisawa J and Seiki M.
    Human T-cell leukemia virus type 1: Molecular biology and its implications in Adult T-cell Leukemia.
    In "Retroviruses in Human Lymphoma/Leukemia", eds. Miwa M, et al., Japan Science Society Press, Tokyo University Press, Utrecht, pp39-47, 1985
  4. Takatsuki k, Yamaguchi K, Watanabe T, Mochizuki M, Kiyokawa T, Mori S, Miyata N.
    Adult T-cell Leukemia and HTLV-1 related Diseases.
    in "Gann Monograph on Cancer Research 39", eds. Takatsuki K, Hinuma Y and Yoshida M.
    Jpn Scientific Society Press, Tokyo, CRC Press, Boca Raton Ann Arbor London Tokyo. pp1-15, 1992.
  5. Yamaguchi K, Mochizuki M, Watanabe T.
    Human T-lymphotropic virus type 1 uveitis.
    Leukemia 8, Suppl. 1: 88-90, 1994
  6. Mochizuki M, Watanabe T, Yamaguchi K, Tajima K.
    "Human T-lymphotropic virus type I associated diseases" in Ocular Infection and Immunity.
    Edited by Pepose J S, Holland G N and Wilhelmus K R. Mosby, 1995, pp1366- 1387.
  7. Mochizuki M, Ono A, Ikeda E, Hikita N, Watanabe T, Yamaguchi K, Sagawa K, Ito K.
    HTLV-1 uveitis.
    J AIDS Hum Retro 13. (Supl 1): S50-56, 1996
  8. Watanabe T, Mochizuki M, Yamaguchi K.
    HTLV-1 uveitis (HU).
    Leukemia. 11 (Suppl 3): 582-584, 1997
  9. Watanabe, T.
    HTLV-1-associated diseases.
    Int J Hematol. 66: 257-278, 1997
  10. Horie R, Watanabe T.
    CD30: Expression and function in health and disease.
    Sem Immunol, 10: 457-470, 1998
  11. Horie R, Higashihara M, Watanabe T.
    Hodgkin's Lymphoma and CD30 signal transduction.
    Int J Hematol. 77:37-47, 2003
  12. Tobinai K, Watanabe T, Jaffe E.
    "HTLV-1-associated adult T-cell leukemia-lymphoma" in Non-Hodgkin Lymphomas.
    Edited by Mauch PM, Armitage JO, Harris NL, Dalla-Favera R, Coiffier B. Lippincott Williams &Wilkins, 2003
  13. Tobinai K and Watanabe T.
    "Chapter 114. Adult T-cell Leukemia-Lymphoma" in Clinical Oncology 3rd Ed.
    Edited by Abeloff MD, Armitage JO, Kastan M, Niederhuber JE. W.B. Saunders, 2003
  14. Yamaguchi K, Watanabe T.
    Human T lymphotropic virus type-I and adult T-cell leukemia in Japan.
    Int J Hematol. 76 (Suppl 2):240-245, 2002.